Bitter rivals Barcelona and Real Madrid meet on Saturday in the sixth 'Clasico' of the season to fight for three crucial points that will shape the destiny of this season's La Liga title.
With five games remaining, Real Madrid go to the Nou Camp four points clear of their great rivals knowing that a win or draw will almost certainly break Barca's dominance and hand Jose Mourinho's side their first title in four seasons.
Real were 10 points clear of the Catalans just over a month ago but have drawn three of the last seven games while Barca have won their last 11 league matches.
Real's run, that has opened the door for Barcelona, began with a 1-1 draw at home to Malaga followed by further draws against Villarreal and Valencia.
The goals of Lionel Messi have been crucial in Barca's recent run -- the Argentine has scored an incredible 18 goals in those 11 wins.
Cristiano Ronaldo has also netted 41 league goals for Madrid making it a head-to-head shoot out between the two best players in the world for the 'Pichichi' prize awarded to the league's top scorer.
Both have earned countless man of the match awards, the tricky recent away wins for both sides at Atletico Madrid standing out for great match-winning goals from the two stars.
Messi has 63 in all competitions to Ronaldo's 53, but if the Portuguese star wins his first La Liga title, against the reigning Spanish, European and World Club Champions, it would surely rank with the best feats in his career to date.
'El Clasico' matches have courted a fair amount of controversy in recent seasons with the appearance of Mourinho on the Madrid bench and his attempts to add a psychological dimension to the clash.
The rivalry boiled over at the beginning of the season when Mourinho poked Barca coach Pep Guardiola's assistant Tito Vilanova in the eye during a game.
Mourinho has only beaten Barca once in 10 attempts since he took over in the summer of 2010.
That victory came in last season's Spanish cup final with a Ronaldo winner in extra-time, but a league title over the Catalans would certainly justify Mourinho's antics in the eyes of 'Madridistas'.
To add more spice, the clash comes the weekend before both sides attempt to turn around first-leg away defeats in the Champions League semi-finals in a bid to meet each other in May's final in Munich.
Real Madrid lost 2-1 to a last-minute goal against Bayern Munich on Tuesday while Barca failed to score in 24 attempts at goal in Wednesday's 1-0 defeat at Chelsea.
In a bid to reduce the pressure on his players Guardiola has continued to reiterate in recent weeks that winning the league is an impossible task.
On Wednesday he was philosophical about his team's defeat and the battles to come.
"I don't know what will happen on Saturday and next Tuesday (the Champions League return leg) but I feel that we have triumphed already," he said cryptically, perhaps referring to Barca's success in recent years.
Mourinho could rest some of his regulars ahead of the Bayern return clash.
Full-back Fabio Coentrao was criticised for his performance in Germany while Mesut Ozil was replaced in the second-half.
To play Karim Benzema or Gonzalo Higuain in attack alongside Ronaldo has also produced great debate all season long.
Guardiola has left Gerard Pique on the bench for the last two games while debate in Barcelona surrounds the form of Cesc Fabregas who has failed to score since early February and Cristian Tello or Pedro Rodriguez could be favoured.
Mallorca v Zaragoza (1600 GMT), Sporting Gijon v Rayo Vallecano (1600 GMT), Barcelona v Real Madrid (1800 GMT), Sevilla v Levante (2030 GMT)
Granada v Getafe (1000 GMT), Real Sociedad v Villarreal (1000 GMT), Racing Santander v Atletico Bilbao (1400 GMT), Atletico Madrid v Espanyol (1600 GMT), Valencia v Real Betis (1930 GMT)
Osasuna v Malaga (1900 GMT)