Heskey was forced off against Palace with a groin problem but both he and Agbonlahor have been able to train this week.
Captain Stiliyan Petrov will retain his starting role at Villa Park as he continues to battle against nagging ankle and Achilles problems.
Full-back Stephen Warnock should also continue after making his comeback from a shin injury against Palace.
Villa (from): Friedel, Cuellar, Warnock, Collins, Dunne, L Young, Downing, Milner, Petrov, A Young, Heskey, Agbonlahor, Carew, Sidwell, Delfouneso, Davies, Delph, Beye, Guzan.
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