Villa manager Martin O'Neill described Reo-Coker's absence as a "major blow", and added that the news regarding full-back Stephen Warnock's shin was also far from encouraging.
Warnock was forced to sit out Wednesday night's goalless draw against Arsenal at Villa Park, and O'Neill said: "We have a couple of injury problems - Nigel and Stephen in particular.
"Nigel will be out for some considerable time - it's turned out to be a stress fracture - so he might miss 12 weeks. That's a major blow to us.
"News on Stephen is not fantastic either, but we'll see."
Aston Villa 13/8, Fulham 13/8, Draw 12/5