Brendan Rodgers' side travel to Eastlands to take on Roberto Mancini's title hopefuls and last season's Championship play-off final winners, who made sure of their place in the top flight with a Wembley win over Reading, will hope to beat City away from home for the first time since 1951.
Up and away: Brendan Rodgers play-off winners begin life in the Barclays Premier League with a visit to Manchester City
Premier League opening fixtures at a glance - with our club-by-club guide below.
Blackburn v WolvesFulham v Aston VillaLiverpool v SunderlandManchester City v SwanseaManchester United v West BromwichNewcastle v ArsenalQPR v BoltonStoke v ChelseaTottenham v EvertonWigan v Norwich Wigan, who ensured their place in the Premier League with a dramatic last day win at Stoke in May, provide the first home opposition for Swansea, meaning a return for former boss Roberto Martinez - who left south Wales for the Latics a little more than two years ago.
The Swans have an appealing final day fixture, with Liverpool visiting The Liberty Stadium on May 13.
Sir Alex Ferguson's men play Roy Hodgson's men at The Hawthorns on August 13, with their next two games at Old Trafford against Tottenham and Arsenal. The champions are set to round off the campaign on May 13 with a match at Sunderland.
Alex McLeish's first game in charge at Aston Villa will take place in the capital where he will face fellow new boss Martin Jol's Fulham side at Craven Cottage.
The Gunners start with a match at Newcastle - a contest which finished in a 4-4 draw last season - while atesting opening continues with a home game against Liverpool before thetrip to Old Trafford.
Away day: Champions Manchester United begin their title defence at West Bromwich Albion
Chelsea, last season's runners-up, travel to Stoke on the opening day, before taking on West Brom at Stamford Bridge.
Liverpool start their campaign at home to Sunderland, meaning Reds midfielder Jordan Henderson will get animmediate match against the team he supported and played for, prior to his recent big money move to Anfield.
The Black Cats' opening home match is against arch-rivals Newcastle the following weekend.
Swansea chairman Huw Jenkins is looking forward to Premier League football.
The Swans start with a trip to Manchester City, before home games against Wigan and Sunderland.
Party time: Swansea celebrate their play-off final win over Reading at Wembley
Jenkins said: 'We are looking forward to it.the main thing is to be competitive.
'Everyone talks about a good start but it's a long season and you've got to be consistent.
'The aim is to keep the club moving forward and luckily we've got an opportunity to do that.'
Of the other Premier League newcomers, QPR open with a home match against Bolton, while Norwich travel to Wigan.Elsewhere on the opening day, Tottenham and Everton meet at White Hart Lane, while Blackburn host Wolves.
QPR boss Neil Warnock said: 'When you see thefixtures it's so exciting. It doesn't matter who you play, the Premier League is where we all want to be.'
On the road: Newly-promoted Norwich travel to Wigan on the opening day of the new 2011/2012 campaign
On his team's own prospects, the QPR boss added on Sky Sports News: 'I think the thing is to try to play without fear.
'We know we're going to have one or two defeats but it's how you bounce back - and our home record's always been good.
'I'm really glad I'm in the Premier League and I've got to make sure whoever plays us it's difficult for them.'
On his squad, he explained: 'The lads that took us up deserve a chance - but I've got to get the right players to make the team better.
Home comforts: Queens Park Rangers host Bolton at Loftus Road on their return to the top flight
'It's difficult at the moment but I'm going to persevere.
'I've spoken to (Blackpool manager) Ian Holloway and he thought where he made a mistake was not getting a squad big enough by the end of August and we don't want to make that mistake if we can help it.'
On the top flight, Warnock added: 'For West Ham to go down with the team they had I find incredible. The league is the tightest it's ever been and for Manchester United to only win five games away from home.you know everyone's in with a shout.
'It's great when teams don't walk away with it. It's going to be very close and very exciting.'
Instant return: Jordan Henderson will welcome his old club to Anfield on the opening day of the season
Norwich manager Paul Lambert admitted the reality of what the Norfolk club had achieved was driven home by this morning's announcement.
He said: 'You look at back-to-back away games at Manchester United and Liverpool in October and that just shows the level we've worked hard to get to.
'We have earned the right to be here - it is a great challenge and exciting times for the club and the fans.
'Whoever we were going to face in the opening game we knew it was going to be a really tough and that is the way it will be in the Premier League, really, really tough games.'
Newcastle boss Alan Pardew was delighted with his team's start.
The Magpies boss said 'What a fantastic start for us, Arsenal at St James' Park and then the Stadium of Light. Our fans will love that, myself and the players are equally excited.
Tough start: Alan Pardew will take his Newcastle side to rivals Sunderland on the second weekend
'No doubt people will hark back to the 4-4 draw last February, and rightly so. It's undoubtedly one of the best games of the opening weekend.
'Going to Sunderland so early in the season is terrific too and of course we can take heart from our performances against them last season.
'Liverpool and Manchester United in successive games over the Christmas-New Year period is pretty mouth-watering too, and two trips to Manchester over consecutive weekends is a tough assignment. But that's what the Premier League is all about and we can't wait.'
Liverpool midfielder Jordan Henderson has been handed the earliest possible reunion with former club Sunderland.
Black Cats boss Steve Bruce said: 'Anfield is always a tough place to go, but we have acquitted ourselves well against the big boys in the past and going there is a test I will relish.
'Then it doesn't get much bigger than a derby game on the first home date of the season.
'It's a difficult start, but everyone is hard at work putting the pieces into place to ensure we have the best squad possible for when the first ball is kicked.'
Club-by-club guide to all the Barclays Premier League fixturesClick here for Arsenal's fixtures
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Click here for all the Championship fixtures 2011-12Click here for all the League One fixtures 2011-12Click here for all the League Two fixtures 2011-12Arsenal's fixtures for the 2011-12 Premier League seasonAston Villa's fixtures for the 2011-12 Premier League seasonBlackburn's fixtures for the 2011-12 Premier League seasonBolton's fixtures for the 2011-12 Premier League seasonNewcastle's fixtures for the 2011-12 Premier League seasonChelsea's fixtures for the 2011-12 Premier League seasonEverton's fixtures for the 2011-12 Premier League seasonFulham's fixtures for the 2011-12 Premier League seasonLiverpool's fixtures for the 2011-12 Premier League seasonMan United's fixtures for the 2011-12 Premier League seasonMan City's fixtures for the 2011-12 Premier League seasonNorwich's fixtures for the 2011-12 Premier League seasonQPR's fixtures for the 2011-12 Premier League seasonStoke's fixtures for the 2011-12 Premier League seasonSunderland's fixtures for the 2011-12 Premier League seasonSwansea's fixtures for the 2011-12 Premier League seasonTottenham's fixtures for the 2011-12 Premier League seasonWest Bromwich's fixtures for the 2011-12 Premier League seasonWigan's fixtures for the 2011-12 Premier League seasonWolves' fixtures for the 2011-12 Premier League season
Explore more:People: Alex Ferguson, Brendan Rodgers, Roberto Mancini, Roberto Martinez, Alex McLeish, Neil Warnock, Ian Holloway, Steve Bruce, Martin Jol, Paul Lambert Places: Newcastle, Liverpool, Norwich, Manchester, Wales