O'Neill points to the example of Chelsea and Liverpool both losing at Wigan as examples of the unpredictability of the Premier League.
The former Celtic boss said: "Are the next two games home bankers? Why would they be? It is a question that riles me in this Premier League.
"It riles me because you see Chelsea going to Wigan and getting beaten, you see Wigan beating Liverpool.
"You see these results. They are there for everyone to see almost every single week. Why would these games be considered banker games for us?
"First there is a derby against a Wolves side who had a terrific result at Burnley last weekend.
"Then we face Sunderland who smashed four goals against Bolton, got their act together again, and then drew with Manchester City.
"The games are tough, they don't work out like that, as bankers, they never have done.
"These games coming up are tough for us. We will have to fight every inch of the way in both games to get anything out of them."
O'Neill feels this unpredictability will mean the race between Villa, Tottenham and Manchester City will ebb and flow during the next two months.
He said: "I think our victory at Wigan has put us back in the picture, although I never felt we were really out of it, and it is going to be like that week in and week out between now and the end of the season.
"There will be upsets, games you have lost, and come into the dressing room and find every result has gone against you, and vice-versa the following week.
"I think it will be like that from now until halfway through May."
Aston Villa 4/11, Draw 7/2, Wolves 17/2