Troubled Portsmouth will take on Birmingham at Fratton Park as they look to emulate their FA Cup victory of 2008.
Fulham face a possible London derby in the quarter-finals, with the Cottagers drawn to play Bolton or Tottenham.
Heading through: Didier Drogba celebrates his goal as Chelsea centered to victory over Cardiff on Saturday
Sixth round draw:
Chelsea v Manchester City or Stoke
Fulham v Bolton or Tottenham
Reading or West Brom v Crystal Palace or Aston Villa
Portsmouth v Birmingham
Ties to be played on the weekend of March 6 and 7
Bolton 1 Tottenham 1: Defoe cancels out Davies' strike to earn Spurs a replayFulham 4 Notts County 0: Cottagers end County's FA Cup dreams Chelsea 4 Cardiff 1: Tough on City as Drogba tweaks the dragon's tail