The League One outfit progressed courtesy of a 2-1 win over Ipswich and will fancy themselves against their nearest rivals when they meet in February.
Cup favourites Chelsea were handed a kind draw, hosting 2008 finalists Cardiff City, while Stoke's reward for their first ever FA Cup triumph over Arsenal is a tricky trip to Manchester City.
On target: Dean Whitehead celebrates his first Stoke City goal
The Midlands could also be a hotbed of cup fever with Derby County drawn against in-form Birmingham City, and Carling Cup finalists Aston Villa potentially facing Wolves. Mick McCarthy's side, though, first need to overcome Crystal Palace in a replay.
Giant-killers Reading, who have already dispensed with Premier League teams Liverpool and Burnley, can expect a stern examination by high-flying Championship side West Brom.
Hot favourites: Chelsea's Nicolas Anelka fires the Blues ahead against Preston
The full fifth round draw, to be played over the weekend of 13/14 February:Wolverhampton Wanderers/Crystal Palace v Aston Villa
Manchester City v Stoke City
Derby County v Birmingham City
Bolton Wanderers v Tottenham/Leeds
Chelsea v Cardiff City
Fulham v Notts County/Wigan
Reading v West Brom
Southampton v Portsmouth
Stoke 3 Arsenal 1: Sol Campbell makes losing return thanks to Ricardo Fuller's double headerNotts County 2 Wigan 2: Watson strikes late to prevent major upsetTottenham 2 Leeds 2: Cup dream lives on for last-gasp hero BeckfordWest Brom 4 Newcastle 2: Magpies grounded by Dorrans double: