Midfielder James Milner, defender Richard Dunne and forward trio Emile Heskey, Gabriel Agbonlahor and John Carew will all be assessed ahead of the trip to the Reebok Stadium.
Goal rush: Carew is now Aston Villa's top scorer
The possible absence of all, or part of, O'Neill's strike-force could mean a rare start for England Under-19 international Nathan Delfouneso.
Team (from): Friedel, Luke Young, Cuellar, Dunne, Collins, Davies, Warnock, Downing, Milner, Petrov, Sidwell, Ashley Young, Carew, Agbonlahor, Heskey, Delfouneso, Guzan, Albrighton, Beye, Clark.
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