But captain John Terry is fit after recovering from the back injury that forced him to withdraw from the England squad ahead of their Euro 2012 qualifier with Montenegro earlier this week.
Fallen to illness: Drogba will miss the trip to Villa Park
Drogba is out with a fever while Lampard has not recovered from a groin strain. Defender Alex is out with a thigh injury and Yossi Benayoun is a long-term absentee with a ruptured Achilles.
Coach Carlo Ancelotti confirmed the Chelsea team: Cech, Ferreira, Ivanovic, Terry, Cole, Ramires, Obi, Essien, Malouda, Kakuta, Anelka. Substitutes from: Mellis, Borini, Van Aanholt, McEachran, Bosingwa, Zhirkov, Turnbull, Hilario.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: John Terry, Didier Drogba, Frank Lampard, Carlo Ancelotti Places: Montenegro, United Kingdom