Ferdinand is out after suffering a twinge in his back while Anderson (knee) is out for the season.
Ryan Giggs (arm) is also out and Nani is suspended while Rafael is set to feature in his first major final.
United have never successfully defended a cup competition before but having overcome Tottenham on penalties last term, could put that statistic right by overcoming Martin O'Neill's men.
Team (from): Van der Sar, Kuszczak, Foster, Rafael, Neville, Brown, Evans, Vidic, De Laet, Evra, Fabio, Valencia, Obertan, Fletcher, Carrick, Scholes, Gibson, Park, Berbatov, Owen, Rooney, Diouf.
Setback: Ferdinand will play no part for United at Wembley
ASTON VILLA FC