Zdenek Zeman has been sacked as coach of Roma a day after the Serie A side suffered a humiliating 4-2 home reverse to Cagliari, the club announced.
Roma's ninth defeat in 23 games, the most of any side in the top half of the table, led 500 fans to protest outside the Stadio Olimpico late on Friday.
General manager Franco Baldini phoned club president James Pallotta in the United States overnight to discuss the situation and after three hours of crisis talks on Saturday Zeman was relieved of his duties.
Aurelio Andreazzoli, 59, will take over as caretaker as Roma look for a permanent successor to Zeman.
Baldini said: "The head coach is not the only one to blame, but we have made our decision and put Andreazzoli in charge of the team."
Former France coach Laurent Blanc was recently linked to the job in reports in the Italian media.