Theo Walcott, Jack Wilshere and Santi Cazorla are poised to return to the starting line-up after dropping to the bench for the FA Cup win at Brighton.
Mikel Arteta (calf) and Francis Coquelin (hamstring) remain out, forward Gervinho is away at the Africa Cup of Nations and goalkeeper Lukasz Fabianski (foot) is not yet in contention.
Liverpool will welcome back fit-again trio Jose Reina, Jose Enrique and Glen Johnson for the game at the Emirates.
Full-back Enrique has not played since suffering a hamstring tear against QPR a month ago while goalkeeper Reina has missed two games with nose and thigh injuries and full-back Johnson sat out the FA Cup defeat by Oldham because of a hamstring problem.
Liverpool boss Brendan Rodgers is likely to revert to a more familiar line-up after heavily criticising his young players for their performance at Boundary Park on Sunday.