Szczesny out of Arsenals Montpellier trip
The Poland international had played in Saturday's 6-1 win over Southampton in the Premier League but let in a sloppy goal shortly before half-time.
Italian goalkeeper Vito Mannone is expected to deputise, having already kept goal in the 0-0 draw with Stoke City and the 2-0 win at Liverpool.
French midfielder Abou Diaby was named in Arsene Wenger's 18-man squad after overcoming a hip problem, but there was no place for Andrey Arshavin, who spent the second part of last season on loan at Zenit Saint Petersburg.
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