The 35-year-old former Spurs centre-half has played six Premier League matches and nine games in all since returning for a second spell with the Gunners.
And he will take his place at the heart of the defence in the north London derby.
Into the lions' den: Campbell (right) returns to White Hart Lane
Wenger said: 'Sol has been a big support for me and the squad. He is very important in the dressing room because he is highly focused and highly motivated.
'Every time he has played he has turned in a very good performance. It is one of the good signings I have made.
'I have no concerns about him. He will play. I didn't imagine he would play as many games as he has.
'I thought he would play in one or two games maybe but he got those extra matches because he played well.'
Campbell spent nine years with Spurs before his controversial switch to Arsenal in 2001.
Arsenal confirm Robin van Persie is back in the squad for crucial north London derbyArsenal powerbroker Stan Kroenke ready to buy out £600m St Louis Rams - so what about Gunners takeover?Jack's the lad for World Cup: Coyle backs Wilshere for EnglandClichy backs Campbell to cope with hostile return to White Hart LaneARSENAL FC