Young Lions boss Stuart Pearce has selected both players in his preliminary 40-man squad for the tournament in Denmark in June.
Jack's the lad: Wilshere has already made 51 appearances for club and country this season
Owen wrote on Twitter: 'Some of them have had long seasons competing in the most physically demanding league in the world.
'(There are) no winter breaks to help them recover. No summer break due to tournament so they will be playing for 2 years without a break.
Making his point: Owen took to Twitter to warn England that they should be careful about burn-out
'At such a young age that's not ideal. I had the same scenario. No breakfor years. International summer tournaments every year without rest.
'It eventually caught up with me. I went BANG towards the end of the season after the (1998) World Cup. Not saying that will happen to these lads.
Agony: Owen's career has been hampered with recurrent hamstring injuries
'(But there are) two sides of the coin to look at. Everyone wants our best players to play as it would enhance our chances of winning it.
'Would be good experience for the players (and) would prepare them well for future International tournaments etc.
Handy Andy: Carroll (right) is also set to feature for the Under 21s this summer
'Just hope we have their interests at heart as I'm sure we do as they are the future. Hard to know what is the right thing to do.'
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Explore more:People: Jack Wilshere, Stuart Pearce, Michael Owen, Andy Carroll Places: United Kingdom