Aston Villa loanee Kyle Walker pulled out to join the senior squad for their game with Denmark, while Manchester United's Chris Smalling, Manchester City's Micah Richards and Sunderland's Jordan Henderson have all picked up knocks.
Called up: Leeds midfielder Howson has benefitted from withdrawls
Also out of the squad are West Ham's James Tomkins, Bolton's on-loan striker Daniel Sturridge, Arsenal full-back Kieran Gibbs and Villa midfielder Fabian Delph.
Leeds captain Jonny Howson has been called into the squad for the first time as a replacement, and has been joined by Chelsea's Josh McEachran, Barnsley's Kieran Tripper, Leicester loanee Kyle Naughton and Crystal Palace forward James Vaughan.
New blow for England as Ferdinand's injury jinx strikes againGerrard to sit out England friendly with groin injury picked up at ChelseaVilla's Walker called up by Capello for England's Denmark friendly Keane set to miss Ireland's clash with Wales after picking up calf injury
Explore more:People: Fabian Delph, James Tomkins, James Vaughan, Stuart Pearce, Daniel Sturridge, Kyle Naughton Places: Italy, Denmark