A victory for Carlo Ancelotti's team would put them 11 points clearof Arsene Wenger's men, having played one more game, and would completea clean sweep of wins over the other members of the Big Four.
End game: Didier Drogba is gunning for Arsenal
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The Ivory Coast striker said: 'It is difficult to come back from 11 points behind. It is not impossible but it would be great to have that gap.
'This is the beginning of a lot of important matches for us. Before the players go to the African Nations Cup, it would be good for us to win all the games.
'I want to be part of this because I know Chelsea are going to miss four or five players. It's important to take the maximum points now.
'After beating Liverpool and United, it would be a big statement to beat Arsenal. But it's going to be a very difficult game.
'Arsenal are playing very well at the moment. They look strong, they don't concede. I think that's where they've improved a lot: they score goals and now they don't concede.
'There's a lot at stake in this game. We really want to win the league this year, so we will go there and try to make a good result.
'We need to maintain the gap between ourselves and the other top-four teams. Maybe it's these games that will decide who are the champions.'
Drogba feels the belief and will to win which characterised the club's back-to-back titles under Jose Mourinho has returned and says that at last being allowed to play up front in partnership with Nicolas Anelka has brought the best out of him.
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