Following the midweek exit to holders Manchester United, the Gunners - safe in fourth place in the Premier League - now have little other than pride left to play for ahead of the summer.
Like Arsenal, the Blues also crashed out of Europe in midweek, losing to a cruel stoppage-time away goal by Barcelona in controversial circumstances at Stamford Bridge.
Wenger believes the events of earlier this week will have an impact on how the players respond on Sunday.
"I believe Chelsea have the right to be more disappointed than us because they were qualified and you could not see how Barcelona could come back," said Wenger, whose side lie six points behind the Blues with three games left.
"The game on Sunday will be down to the team who deals best with the disappointment, who wants it more and who has more strength of character."
Wenger added: "Afterwards people always take definite conclusions, but I believe that the distance between the two teams is not as big as people make it today.
"For me it is not hard to try to re-motivate the players, but what is hard is to get the players' belief, desire and a bit of joy back in the squad.
"However, this team have no attitude problem, they always train focused and well."
Arsenal 6/4, Chelsea 15/8, Draw 9/4