Alejandro Sabella's Argentina will be out for revenge on Wednesday when they take on longtime rivals Brazil in their "Superclasico de las Americas" return in the northern city of Chaco.
Brazil won the opening encounter in Goiana on September 19 since when Sabella has tweaked a homegrown squad with the arrival of striker Ignacio Scocco from Newell's Old Boys.
Both countries will be playing young home-based stars with top names such as the hosts' Leo Messi in European action for their clubs.
The match will be played in the modest northern city of La Resistencia, home to second tier Zone B side Chaco for Ever.
The match allows Sabella and Brazil counterpart Mano Menezes will use the occasion to see what emerging talents are likely to blossom in time for the 2014 World Cup.
Adding a little spice to the occasion is the fact that four of the Argentinians ply their club trade in Brazil - strikers Juan Manuel Martinez of Corinthians and Hernan Barcos of Palmeiras and midfielders Pablo Guinazu from Internacional Porto Alegre and Cruzeiro's Walter Montillo.
Barcos is a potential call-up for upcoming World Cup qualifiers against reigning South American champions Uruguay and Chile.
Brazil are pre-qualified as holders, hence Menezes can delve into his youth ranks with less riding on the immediate outcome, whereas Argentina have to ensure they bag a berth in the regional qualifiers.
They currently head the group.
"We shall have to play it differently and go for it more than we did in Brazil," said Barcos.
But he added that Sabella had generally been "pleased with the performance as we turned in an intelligent showing and what was missing was really only the result."
"We're working on a few tactical things," added Maximiliano Rodriguez of Newell's Old Boys, voicing the hope that the home crowd would also make a difference.
Brazil star Neymar, fresh from winning the Recopa Sudamericana title with Santos against Universidad de Chile said meanwhile that "playing against Argentina is different than against other nations. I always like to meet them."
Neymar is set to start in attack alongside Leandro Damiao, a mainstay of Brazil's Olympic runners-up - he finished tournament top scorer and who plays for SC Internacional of Porto Alegre.