Annan wait on Black and Weatherson in bid to overhaul Clyde
Fifth-placed Annan welcome fourth-placed Clyde with the Galabank side hoping defender Steven Black and top goalscorer Peter Weatherson will be available after injuries.
Steven Swinglehurst (hamstring), Jack Breslin (foot) and Bryan Gilfillan (calf) have been ruled out while manager Jim Chapman is determined his side do not invite pressure on themselves.
Chapman said: "In our last two home games we have had two-goal leads and ended up with just two points.
"One of the reasons is that three penalties have been given against us and we have to ensure that we stop giving referees the option to make these decisions in our box."
Clyde will be without striker David Gormley, who is serving the second game of a two-match ban and they also have a doubt over forward John Gemmell, who has a calf problem.
Brian McQueen, Scott McMann and Scott Ferguson all remain sidelined with knee injuries.
Manager Barry Ferguson said: "After winning three games in a row it was really disappointing to lose to East Stirling in midweek.
"We have spent a long time looking at what needs to be fixed and we will look to put things right at Annan.
"I am looking for a positive reaction from the players as everyone was hurting after losing."